Differentiating founder and chronic HIV envelope sequences
نویسندگان
چکیده
منابع مشابه
Differentiating founder and chronic HIV envelope sequences
Significant progress has been made in characterizing broadly neutralizing antibodies against the HIV envelope glycoprotein Env, but an effective vaccine has proven elusive. Vaccine development would be facilitated if common features of early founder virus required for transmission could be identified. Here we employ a combination of bioinformatic and operations research methods to determine the...
متن کاملPhenotypic and immunologic comparison of clade B transmitted/founder and chronic HIV-1 envelope glycoproteins.
Sexual transmission of human immunodeficiency virus type 1 (HIV-1) across mucosal barriers is responsible for the vast majority of new infections. This relatively inefficient process results in the transmission of a single transmitted/founder (T/F) virus, from a diverse viral swarm in the donor, in approximately 80% of cases. Here we compared the biological activities of 24 clade B T/F envelope...
متن کاملTransmitted/founder and chronic HIV-1 envelope proteins are distinguished by differential utilization of CCR5.
Infection by HIV-1 most often results from the successful transmission and propagation of a single virus variant, termed the transmitted/founder (T/F) virus. Here, we compared the attachment and entry properties of envelope (Env) glycoproteins from T/F and chronic control (CC) viruses. Using a panel of 40 T/F and 47 CC Envs, all derived by single genome amplification, we found that 52% of clade...
متن کاملThe unrooted set covering connected subgraph problem differentiating between HIV envelope sequences
This paper presents a novel application of operations research techniques to the analysis of HIV env gene sequences, aiming to identify key features that are possible vaccine targets. These targets are identified as being critical to the transmission of HIV by being present in early transmitted (founder) sequences and absent in later chronic sequences. Identifying the key features of env involv...
متن کاملTitle: Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition
226 words) 23 Vertical HIV-1 transmission via breastfeeding is the predominant contributor to pediatric 24 infections that are ongoing in this era of highly effective antiretroviral therapy (ART). 25 Remarkably, only ~10% of infants chronically exposed to the virus via breastfeeding from 26 untreated HIV-infected mothers become infected, suggesting the presence of naturally protective 27 factor...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2017
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0171572